Valproic Acid Positive Effects in Parkinson’s Disease
نویسنده
چکیده
Figure 1: Pathway of Parkinson’s disease characterised by the degeneration of dopaminergic cells in the substantia nigra pars compacta. Above is a flow-chart describing the pathway of Parkinson’s disease characterised by the degeneration of dopaminergic cells in the substantia nigra pars compacta located in the basal ganglia [1]. The SNc (Substantia Nigra Pars Compacta) is what that is affected by Parkinson’s disease and evidently its influence is only one way, it is unimpacted by any other part of the ganglia.
منابع مشابه
Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines
Objective(s): Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties.In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV positive cell lines. Materials and Methods: Cell lines were treated by2 mmol/...
متن کاملThe contribution of S100B to the glioprotective effects of valproic and arundic acids
Objective(s): Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer’s disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective effects of valproic and arundic acids against amyloid-β-peptide (Aβ)-induced glial death and co...
متن کاملبررسی اثر ضد آپوپتوزی والپروئیک اسید در مدل موشی ضایعه نخاعی
Background and Objective: Spinal cord injury (SCI) leads to the loss of axons and cell death via necrosis and apoptosis, eventually resulting in sensory and motor dysfunction. The aim of this study was to evaluate the effects of valproic acid on the inhibition of apoptosis and the improvement of motor function in the rat model of spinal cord injury. Materials and Methods: Contusion model was u...
متن کاملProtective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid
Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested. In this study, considering the chemical composition of catechins, we investigated its protective effect on the survival of PC12 nerve cells exposed to valproic acid. Materials and methods: The protective effects of epicatechin (EC)...
متن کاملEllagic Acid Protects the Brain Against 6-Hydroxydopamine Induced Neuroinflammation in a Rat Model of Parkinson’s Disease
Introduction: Neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. Antioxidants have protective effects against free radicalsinduced neural damage in Parkinson’s disease (PD). In the present study, we examined the effects of ellagic acid (EA) on locomotion and neuroinflammatory biomarkers in a rat model of PD induced by 6-hydroxidopamin...
متن کامل